Postdoctoral fellow in in vitro / ex vivo ADME liquid biopsy
We are a global and independent mid-sized pharmaceutical group governed by a Foundation. Our unique model makes us proud and, more importantly, enables us to fully serve our mission: "committed to therapeutic progress for the benefit of patients."
As a global leader in cardiology, we aim to become a focused and innovative player in oncology by 2030, targeting hard-to-treat cancers and dedicating more than 70% of our R&D budget to this goal.
Who are we? 20,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.
Come and experience and contribute to our commitment #MovedByYou.
About our R&D Institute in Paris Saclay
At the heart of one of the world's top eight innovation clusters, the Servier R&D Institute at Paris-Saclay is where visionary science meets a powerful global ecosystem. By uniting our Group's innovation potential with this prestigious center of excellence, we are not only accelerating the future of therapeutic discovery but also championing the global influence of French research.
Are you a fast-learning scientist passionate about optimizing clinical drug trials through the investigation of endogenous biomarkers ? We are seeking a Scientist to join our R&D organization. In this role, you will develop robust protocols to extract liver-derived extracellular vesicles (EVs) from culture media and human plasma and apply MultiOMICS (Proteomics and Transcriptomics) to monitor CYP450 and drug transporter induction/inhibition. Your work will reduce reliance on dedicated clinical DDI studies and feed into our global DDI monitoring strategy throughout clinical development.
Responsibilities
- Design and conduct experiments with primary human hepatocytes, relevant cell lines, and human samples to set up, test, and optimize liver-derived EV isolation/enrichment protocols
- Evaluate the reliability of EV-based readouts to assess xenobiotic impacts on ADME protein expression (CYP450 and drug transporters induction/inhibition)
- Optimize sample preparation to maximize data yield from minimal plasma volumes
- Perform quantitative studies of global protein and gene expression in extracted EVs and monitor induction effects
- Work transversally with scientists across R&D to execute experiments and generate/analyze proteomics and transcriptomics datasets
- Communicate results internally (presentations/posters) and externally (peer-reviewed journals, posters, conferences), where applicable
- Contribute to general lab activities, including mentoring undergraduate/graduate students and participating in science outreach, where applicable
Profile
- PhD in biochemistry, molecular biology, cell biology, or equivalent
- Proven experience with extracellular vesicle extraction and analysis
- Expertise in sample preparation and core biochemical methods (WB, ELISA, qPCR)
- Proficiency in proteomics, genomics, and transcriptomics is valued
- Some bioinformatics experience for protein identification and gene expression analysis
- Knowledge of pharmacokinetics and cell culture is a plus (not required)
- Ability to mentor internship- or technician-level collaborators
- Team-oriented, results-driven, curious, and autonomous
- Strong communication skills with demonstrated experience writing and publishing in international peer-reviewed journals
Our standard recruitment journey includes the following steps:
- Prequalification Interview
- Interview with the Manager
- Interview with Talent Acquisition Team / Human Resources
- Reference Check Process
At one stage of the process, we would be delighted to welcome you to our site to meet in person and share the environment where we work every day to transform patients' lives!
Please note that this recruitment process may be adapted based on the specific requirements of the position.
Our Benefits
- 13th-month salary, contribution to results bonus, profit-sharing / employee participation, and transportation allowance
- 27 days of paid leave, plus 23 RTT days (reduced working hours)
- Flexible remote work options depending on the role
- On-site company restaurant, and a wide range of employee committee (CSE) activities and associations
We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!